Leukemia is a broad-spectrum disease that comprises various types of blood cancers. Chronic eosinophilic leukemia is one of its types. Eosinophils are the subcategory of white blood cells involved in the body’s defense mechanism to ward off infections and destroy foreign particles. In eosinophilic leukemia, the eosinophils levels are elevated due to genetic mutation. However, there are various causes for gene mutation, and one of the significant factors includes environmental factors and radiation exposure. In chronic eosinophilic leukemia, there is an excessive accumulation of eosinophils in the bone marrow which tends to cause organ damage. It has been identified that eosinophilic leukemia is more common in men than women.
Eosinophilic leukemia is also addressed as myeloproliferative neoplasm, a condition with excessive blood cell production. It is a rare type of blood cancer that affects people in the 20-50 years age group, yet they are common in children and elderly persons. They are usually presented with non-specific symptoms. People affected with eosinophilic leukemia may experience certain signs and symptoms that include fever, night sweats, muscle pain, dramatic weight loss, breathlessness, severe cough, and persistent fatigue. If the eosinophilic leukemia is left untreated, it may gradually progress into acute myelogenous leukemia. It has been projected that the survival rates for people affected with chronic eosinophilic leukemia range between 1 and 5 years. Chronic eosinophilic leukemia will be diagnosed based on the test reports of complete blood count, bone marrow biopsy, and imaging studies to identify any organ damage. However, cancer therapy varies from individual based on the condition and stages. The treatment options for chronic eosinophilic leukemia involve chemotherapy, targeted drug therapy, and immunotherapy. With the up-gradation of cancer targeted therapy, oncologists recommend targeted drug therapy that inhibits specific genes responsible for triggering the leukemia cells. Imatinib is a drug that has been used predominantly in the treatment of chronic eosinophilic leukemia. Imatinib produces its action by blocking the production and function of tyrosine kinase enzymes, which is involved in the cell division of blood cells. Thus, it produces signals to prevent the cell division of abnormal white blood cells and stops the further development of malignant cells. In addition to this, Imatinib has another role in ceasing the FIP1 platelet growth factor that plays a vital role in developing abnormal eosinophils. Imatib is one such product that consists of Imatinib, it is available as a Imatib 100 mg and Imatib 400mg tablet. Imatib is not only used in the treatment of chronic eosinophilic leukaemia, it is also used in treating stomach cancer (gastrointestinal stromal tumours), skin cancer and myeloid leukemia. However, consult your doctor about the dose and the duration of use. If you have been diagnosed with chronic eosinophilic leukemia recently, discuss it with your doctor, and they will develop a tailor-made treatment plan to alleviate the condition.
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5/2/2022 What is liver cancer & hepatocellular carcinoma (HCC)? How does Sorafenib help treat HCC?Read NowThe liver is the largest internal organ that helps with many important body functions such as blood clotting, removal of toxins, and digestion. Liver cancer is the uncontrolled production of abnormal cells in the liver. When cancer begins in the liver, it is called primary liver cancer, and cancers that started elsewhere and spread to the liver are called secondary liver cancers. The most common cancers that spread to the liver include colorectal cancer, breast cancer, and lung cancer. Hepatocellular carcinoma is the most common type of primary liver cancer and accounts for about 90% of primary liver cancer cases.
Men aged sixty and above are more likely to develop hepatocellular carcinoma than younger men and women. Cirrhosis (scarring of liver tissue) from hepatitis infections, heavy alcohol drinking, or non-alcoholic fatty liver disease is the most common cause of hepatocellular carcinoma. The other medical conditions that increase the risk of HCC are obesity and diabetes. Smoking can also increase the risk. If you smoke, drink alcohol or have any of the above-said diseases, talk to the health care professional about being screened for HCC. He/ she can perform tests such as ultrasound to check for abnormalities in the liver and help you formulate lifestyle changes, and prescribe medicines to decrease the risk of HCC. Hepatocellular carcinoma symptoms include unintentional weight loss, nausea, vomiting, stomach pain, skin itching, yellow skin or whites of the eyes, loss of appetite, feeling fullness under the ribs, pain near the right shoulder, and a feeling of swollen stomach. Blood tests, imaging tests (such as MRI), and liver biopsy are used to confirm the diagnosis. The physician may recommend treatment for hepatocellular cancer depending on the tumor size, its location, liver function and overall health. If the cancer is in an early stage, surgery may be the preferred option. A liver transplant may be done when the tumor is small and doesn’t spread to nearby blood cells. If the tumor location makes surgery not possible or if the cancer size is big, physicians may recommend other treatment options. These include radiation therapy, radiofrequency ablation, chemoembolization, targeted therapy and chemotherapy. Sorafenib is the targeted therapy for hepatocellular carcinoma, meaning that it precisely recognizes and attacks the specific types of cancer cells. Sorafenib blocks the action of many abnormal proteins that signal the cancers to multiply and stops the blood supply to the tumor cells to prevent them from growing. Sorafenib is also used in the treatment of other cancers such as advanced renal cell carcinoma and differentiated thyroid carcinoma. Soranib 200mg Tablet is one of the products containing the active substance sorafenib. If you have hepatocellular carcinoma, advanced renal cell carcinoma, or differentiated thyroid carcinoma, your physician may prescribe Soranib 200 mg Tablet. This medicine may cause harm to the unborn child, and it is important to use effective birth control during the treatment and for at least six months after the treatment ends. |
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