Did you know? Colorectal cancer is among the top 5 commonly diagnosed cancers in India. Colorectal cancer occurs in the large intestine due to the rapid multiplication of cells lining the colon or rectum. It can begin either in the colon or rectum; hence they are collectively named colorectal cancer.
Although colorectal cancer does not present any early symptoms, some chief indications for colorectal cancer are to be noticed seriously. These include a persistent change in bowel movement, constipation, diarrhea or incomplete bowel emptying, inconsistency in stool, rectal bleeding, drastic weight loss, and abdominal pain, gastric trouble, and vomiting. The majority of Colorectal cancer usually starts as polyps. They are non-cancerous at the initial stage, however, if it is left untreated for 10-15 years they can grow further and become cancerous. There are specific causes and risk factors for the development of colorectal cancers. It has been suggested that colorectal cancer occurs due to the combination of genetic and lifestyle factors. Generally, people who have a family history of colorectal cancer, personal history of inflammatory bowel disease, and of polyps are at extreme risk of getting colorectal cancer. In addition to this, some lifestyle factors such as having a low fibre diet, sedentary lifestyle, chronic alcoholism, smoking, and consuming foods that have been prepared at high temperatures, such as processed meat and high fatty foods can contribute to causing colorectal cancer. Colorectal cancer is the most preventable and treatable cancer if it’s diagnosed at an early stage. Colorectal can be prevented if it is screened regularly. Due to a lack of awareness about the screening test, most of the patients in India are diagnosed at advanced stages of colorectal cancer and are subjected to low survival rates. Healthcare professionals in India recommend having a colonoscopy screening for those above 45 years coupled with an annual stool examination known as the fecal occult blood test to detect the presence of blood in stool. Colonoscopy screening is a standard tool which can detect the presence of polyps and with this screening method, the colorectal polyps can be removed easily by preventing them from developing into malignant polyps. However, there are several diagnosis methods to detect colorectal cancers, including CT scan, sigmoidoscopy, and biopsy. Treatment of colorectal cancer usually involves a combination of surgery, chemotherapy and radiation therapy. Since colorectal cancer is the most treatable cancer there are few best treatment options to manage colorectal cancer with advancements in cancer research. Researchers have developed new types of medications that target cancerous tumors and bevacizumab is one of the few effective targeted drug therapies available, which is used in part of chemotherapy to reduce the size of colorectal cancer tumors. Bevacizumab is indicated as the first-line treatment for metastatic colorectal cancer and it is used in combination with intravenous fluorouracil during chemotherapy. Bevacizumab is a monoclonal antibody that acts by inhibiting the vascular endothelial growth factor, a receptor that is present in the blood vessels. Thus, it retards the growth of tumor growth by inhibiting the formation of blood vessels, thereby declining cancer progression. Bevacizumab is prescribed for the intravenous route of administration and injected as an infusion to your body. Avastin is one of the products containing this active constituent and is available as Avastin 400mg injection and Avastin 100 mg injection in the market. Apart from its use in the treatment of colorectal cancer, bevacizumab is also indicated for non-small cell lung cancer, advanced stage of cervical cancer and renal cell carcinoma. Thus, drugs like these involved in targeted therapy can often help people diagnosed with advanced colorectal cancer live longer.
1 Comment
6/19/2023 04:34:40 am
I appreciate your mentioning that colonoscopy screening is a common approach for detecting the existence of polyps and that by using this method, colorectal polyps may be easily removed by preventing the development of malignant polyps. My companion felt suspicious mounds in her stomach that seemed like polyps. I'll arrange for her to get a colonoscopy to check for polyps.
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